This study focuses on the binding affinity of chemicals that are the components of widely used cosmetics, with human DNA and CYP1A2 protein, which is involved in there deactivation and excretion. Study was carried on the 21 selected possibly toxic chemicals which may be involved in DNA adduct formation and show possible proteins binding affinity, then a docking analysis has been performed by an automated docking server known as Patchdock. The five chemicals with highest Patch Dock scores with both DNA and CYP1A2 were mostly found to be important ingredient of many cosmetic products. Among these five chemicals four chemicals were found to be common namely oleic acid, polyethelene-glycol, alpha-tocopherol, and steric acid which show they have highest binding affinity towards both DNA and protein.

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