Fibroblast growth factor 1 (FGF1) is an autocrine/paracrine regulator whose binding to heparan sulphate proteoglycans effectively precludes its circulation. Although FGF1 is known as a mitogenic factor, FGF1 knockout mice develop insulin resistance when stressed by a high-fat diet, suggesting a potential role in nutrient homeostasis. Here we show that parenteral delivery of a single dose of recombinant FGF1 (rFGF1) results in potent, insulin-dependent lowering of glucose levels in diabetic mice that is dose-dependent but does not lead to hypoglycaemia.
Technology Partners: MimirTech
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/endocrinization-fgf1-produces-neomorphic-and-potent-insulin-sensitizer
[2] http://admin.indiaenvironmentportal.org.in/category/author/jae-myoung-suh
[3] http://admin.indiaenvironmentportal.org.in/category/author/johan-w-jonker
[4] http://admin.indiaenvironmentportal.org.in/category/author/maryam-ahmadian-et-al
[5] http://admin.indiaenvironmentportal.org.in/category/journal/nature
[6] http://admin.indiaenvironmentportal.org.in/category/thesaurus/diabetes
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/medical-research
