Multiple host molecules are known to be involved in the cellular entry of filoviruses, including Ebola virus (EBOV); T-cell immunoglobulin and mucin domain 1 (TIM-1) and Niemann-Pick C1 (NPC1) have been identified as attachment and fusion receptors, respectively. However, the molecular mechanisms underlying the entry process have not been fully understood. We found that TIM-1 and NPC1 colocalized and interacted in the intracellular vesicles where EBOV glycoprotein (GP)-mediated membrane fusion occurred.
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/interaction-between-tim-1-and-npc1-important-cellular-entry-ebola-virus
[2] http://admin.indiaenvironmentportal.org.in/category/author/makoto-kuroda
[3] http://admin.indiaenvironmentportal.org.in/category/author/daisuke-fujikura
[4] http://admin.indiaenvironmentportal.org.in/category/author/asuka-nanbo-et-al
[5] http://admin.indiaenvironmentportal.org.in/category/journal/journal-virology
[6] http://admin.indiaenvironmentportal.org.in/category/thesaurus/ebola-virus-disease-ebola-hemorrhagic-fever
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/research