To maintain a symbiotic relationship between the host and its resident intestinal microbiota, appropriate mucosal T cell responses to commensal antigens must be established. Mice acquire both IgG and IgA maternally; the former has primarily been implicated in passive immunity to pathogens while the latter mediates host-commensal mutualism. Here, we report the surprising observation that mice generate T cell-independent and largely Toll-like receptor (TLR)-dependent IgG2b and IgG3 antibody responses against their gut microbiota. We demonstrate that maternal acquisition of these antibodies dampens mucosal T follicular helper responses and subsequent germinal center B cell responses following birth. This work reveals a feedback loop whereby T cell-independent, TLR-dependent antibodies limit mucosal adaptive immune responses to newly acquired commensal antigens and uncovers a broader function for maternal IgG.
Original Source [2]
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/maternal-igg-and-iga-antibodies-dampen-mucosal-t-helper-cell-responses-early-life
[2] http://www.cell.com/fulltext/S0092-8674(16)30500-1
[3] http://admin.indiaenvironmentportal.org.in/category/author/meghan-koch
[4] http://admin.indiaenvironmentportal.org.in/category/author/gabrielle-l-reiner
[5] http://admin.indiaenvironmentportal.org.in/category/author/kyler-lugo-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/cell
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/breast-feeding
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/child-health
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/micro-organisms
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/research