Widespread use of oral poliovirus vaccine has led to an ≈99.9% decrease in global incidence of poliomyelitis (from ≈350,000 cases in 1988 to 74 cases in 2015) and eradication of wild-type poliovirus serotypes 2 and 3. However, patients with primary immunodeficiency might shed vaccine-derived polioviruses (VDPVs) for an extended period, which could pose a major threat to polio eradication programs. Since 1995, sixteen VDPV populations have been isolated from 14 patients with immunodeficiency in Iran. For these patients, vaccine-associated paralysis, mostly in >1 extremity, was the first manifestation of primary immunodeficiency.
Original Source [2]
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/vaccine-derived-polioviruses-and-children-primary-immunodeficiency-iran-1995%E2%80%932014
[2] http://wwwnc.cdc.gov/eid/article/22/10/15-1071_article
[3] http://admin.indiaenvironmentportal.org.in/category/author/mohammadreza-shaghaghi
[4] http://admin.indiaenvironmentportal.org.in/category/author/shohreh-shahmahmoodi
[5] http://admin.indiaenvironmentportal.org.in/category/author/hassan-abolhassani-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/emerging-infectious-diseases
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/polio
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/child-health
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/iran
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/vaccination