Designing biologically inspired nanoscale molecular assembly with desired functionality is a challenging endeavour. Here we report the designing of fbrin-inspired nanostructured peptide based sealants which facilitate remarkably fast entrapping of blood corpuscles (~28 seconds) in contrast to fbrin (~56 seconds). Our engineered sealants are stabilized by lysine-aspartate ionic interactions and also by Nε (γ-glutamyl) lysine isopeptide bond mediated covalent interaction. Each sealant is formed by two peptides having complementary charges to promote lysine-aspartate ionic interactions and designed isopeptide bond mediated interactions.
Original Source [2]
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/engineered-isopeptide-bond-stabilized-fibrin-inspired-nanoscale-peptide-based
[2] https://www.nature.com/articles/s41598-017-06360-3.pdf
[3] http://admin.indiaenvironmentportal.org.in/category/author/snehasish-ghosh
[4] http://admin.indiaenvironmentportal.org.in/category/author/sanchita-mukherjee
[5] http://admin.indiaenvironmentportal.org.in/category/author/chiranjit-dutta-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/scientific-reports
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/blood
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/research
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/india