Phosphatidylinositol 3,4,5-trisphosphate (PIP3) generation at the plasma membrane is a key event during activation of receptor tyrosine kinases such as the insulin receptor required for normal growth and metabolism. [2] The researchers report that in Drosophila, phosphatidylinositol 5 phosphate 4-kinase (PIP4K) is required to limit PIP3 levels during insulin receptor activation. Depletion of PIP4K increases the levels of PIP3 produced in response to insulin stimulation.
Original Source [3]
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/phosphatidylinositol-5-phosphate-4-kinase-regulates-plasma-membrane-pip3-turnover
[2] http://www.indiaenvironmentportal.org.in/files/file/Phosphatidylinositol.pdf
[3] https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30564-9
[4] http://admin.indiaenvironmentportal.org.in/category/author/sanjeev-sharma
[5] http://admin.indiaenvironmentportal.org.in/category/author/swarna-mathre
[6] http://admin.indiaenvironmentportal.org.in/category/author/visvanathan-ramya-et-al
[7] http://admin.indiaenvironmentportal.org.in/category/journal/cell-reports
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/diabetes
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/medical-research
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/india