This report outlines the results of a scientific study of the impacts of weather, climate variability, and climate change on health in Mozambique, with a focus on diarrheal disease and malaria. The principal objective of this work is to build a scientific knowledge base to support informed investments and decision making in the health sector in Mozambique. The findings will help to shape the Ministry of Health’s (MoH) preparedness and response to emerging climate risks by working in concert with Mozambique’s new National Climate and Health Observatory, which combines weather and climate data to predict disease outbreaks, raise awareness of weather and climate impacts on health, and encourage government and public discourse on climate sensitive health issues.