Chrysotile asbestos accounts for more than 90% of the asbestos used worldwide and exposure is associated with asbestosis (asbestos-related fibrosis) and other malignancies, but the molecular mechanisms involved are not fully understood. A common pathogenic mechanism for these malignancies is represented by epithelial-mesenchymal transition (EMT), through which epithelial cells undergo a morphological transformation to take on a mesenchymal phenotype. In the present work we propose that chrysotile asbestos induces EMT through a mechanism involving a Tranforming Growth Factor beta (TGFβ)-mediated signaling pathway.
Original Source [2]
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/effect-chrysotile-exposure-human-bronchial-epithelial-cells-insights-pathogenic
[2] http://ehp.niehs.nih.gov/14-09627/
[3] http://admin.indiaenvironmentportal.org.in/category/author/giulia-rossana-gulino
[4] http://admin.indiaenvironmentportal.org.in/category/author/manuela-polimeni
[5] http://admin.indiaenvironmentportal.org.in/category/author/mauro-prato-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/environmental-health-perspectives
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/asbestos
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/health-effects
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/asbestosis