Among the several new antimalarials discovered over the past decade are at least three clinical candidate drugs, each with a distinct chemical structure, that disrupt Na+ homeostasis resulting in a rapid increase in intracellular Na+ concentration ([Na+]i) within the erythrocytic stages of Plasmodium falciparum. At present, events triggered by Na+ influx that result in parasite demise are not well-understood. Here we report effects of two such drugs, a pyrazoleamide and a spiroindolone, on intraerythrocytic P. falciparum.
Original Source [2]
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Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/na-influx-induced-new-antimalarials-causes-rapid-alterations-cholesterol-content-and
[2] http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005647
[3] http://admin.indiaenvironmentportal.org.in/category/author/sudipta-das
[4] http://admin.indiaenvironmentportal.org.in/category/author/suyash-bhatanagar
[5] http://admin.indiaenvironmentportal.org.in/category/author/joanne-m-morrisey-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/plos-pathogens
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/malaria
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/medical-research
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/vector-borne-diseases
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/drugs
