Dengue is the most prevalent arboviral disease in humans and a major public health problem worldwide. Systemic plasma leakage, leading to hypovolemic shock and potentially fatal complications, is a critical determinant of dengue severity. Recently, we and others described a novel pathogenic effect of secreted dengue virus (DENV) non-structural protein 1 (NS1) in triggering hyperpermeability of human endothelial cells in vitro and systemic vascular leakage in vivo.
Original Source [2]
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Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/dengue-virus-ns1-disrupts-endothelial-glycocalyx-leading-hyperpermeability
[2] http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005738
[3] http://admin.indiaenvironmentportal.org.in/category/author/henry-puerta-guardo
[4] http://admin.indiaenvironmentportal.org.in/category/author/dustin-r-glasner
[5] http://admin.indiaenvironmentportal.org.in/category/author/eva-harris
[6] http://admin.indiaenvironmentportal.org.in/category/journal/plos-pathogens
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/dengue
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/medical-research
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/vector-borne-diseases
