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Home > Featured Articles > BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity > BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity

BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity [1]

The tuberculosis vaccine bacillus Calmette-Guérin (BCG) has heterologous beneficial effects against non-related infections. [2] The basis of these effects has been poorly explored in humans. In a randomized placebo-controlled human challenge study, we found that BCG vaccination induced genome-wide epigenetic reprograming of monocytes and protected against experimental infection with an attenuated yellow fever virus vaccine strain.

Original Source [3]

Publication Date: 
10/01/2018
Rob J.W. Arts [4], Simone J.C.F.M. Moorlag [5], Boris Novakovic & et al [6]
Cell Host & Microbe [7]
23
1
89-100
Tags:
Viral Diseases [8], Vaccination [9], Medical Research [10], Infectious Diseases [11], Tuberculosis [12], Health Effects [13]
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Source URL: http://admin.indiaenvironmentportal.org.in/feature-article/bcg-vaccination-protects-against-experimental-viral-infection-humans-through

Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/bcg-vaccination-protects-against-experimental-viral-infection-humans-through
[2] http://www.indiaenvironmentportal.org.in/files/file/BCG-vaccination-viral-infection.pdf
[3] https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(17)30546-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1931312817305462%3Fshowall%3Dtrue
[4] http://admin.indiaenvironmentportal.org.in/category/author/rob-jw-arts
[5] http://admin.indiaenvironmentportal.org.in/category/author/simone-jcfm-moorlag
[6] http://admin.indiaenvironmentportal.org.in/category/author/boris-novakovic-et-al
[7] http://admin.indiaenvironmentportal.org.in/category/journal/cell-host-microbe
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/viral-diseases
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/vaccination
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/medical-research
[11] http://admin.indiaenvironmentportal.org.in/category/thesaurus/infectious-diseases
[12] http://admin.indiaenvironmentportal.org.in/category/thesaurus/tuberculosis
[13] http://admin.indiaenvironmentportal.org.in/category/thesaurus/health-effects