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Home > Featured Articles > Induction of multidrug tolerance in Plasmodium falciparum by extended Artemisinin pressure > Induction of multidrug tolerance in Plasmodium falciparum by extended Artemisinin pressure

Induction of multidrug tolerance in Plasmodium falciparum by extended Artemisinin pressure [1]

Plasmodium falciparum resistance to artemisinin derivatives in Southeast Asia threatens global malaria control strategies. Whether delayed parasite clearance, which exposes larger parasite numbers to artemisinins for longer times, selects higher-grade resistance remains unexplored. We investigated whether long-lasting artemisinin pressure selects a novel multidrug-tolerance profile. Although 50% inhibitory concentrations for antimalarial drugs tested were unchanged, drug-tolerant parasites showed higher recrudescence rates for endoperoxides, quinolones, and an antifolate, including partner drugs of recommended combination therapies, but remained susceptible to atovaquone.

Original Source [2]

Publication Date: 
01/10/2015
Sandie Ménard [3], Tanila Ben Haddou [4], Arba Pramundita Ramadani & et al [5]
Emerging Infectious Diseases [6]
21
10
Tags:
Vector Borne Diseases [7], Drugs [8], Malaria [9], Vector Control [10], Cambodia [11]
Centre for Science and Environment
National Knowledge Commission Government of India

Technology Partners: MimirTech


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Source URL: http://admin.indiaenvironmentportal.org.in/feature-article/induction-multidrug-tolerance-plasmodium-falciparum-extended-artemisinin-pressure

Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/induction-multidrug-tolerance-plasmodium-falciparum-extended-artemisinin-pressure
[2] http://wwwnc.cdc.gov/eid/article/21/10/15-0682_article
[3] http://admin.indiaenvironmentportal.org.in/category/author/sandie-m%C3%A9nard
[4] http://admin.indiaenvironmentportal.org.in/category/author/tanila-ben-haddou
[5] http://admin.indiaenvironmentportal.org.in/category/author/arba-pramundita-ramadani-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/emerging-infectious-diseases
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/vector-borne-diseases
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/drugs
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/malaria
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/vector-control
[11] http://admin.indiaenvironmentportal.org.in/category/thesaurus/cambodia