Plasmodium falciparum resistance to artemisinin derivatives in Southeast Asia threatens global malaria control strategies. Whether delayed parasite clearance, which exposes larger parasite numbers to artemisinins for longer times, selects higher-grade resistance remains unexplored. We investigated whether long-lasting artemisinin pressure selects a novel multidrug-tolerance profile. Although 50% inhibitory concentrations for antimalarial drugs tested were unchanged, drug-tolerant parasites showed higher recrudescence rates for endoperoxides, quinolones, and an antifolate, including partner drugs of recommended combination therapies, but remained susceptible to atovaquone.
Original Source [2]
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/induction-multidrug-tolerance-plasmodium-falciparum-extended-artemisinin-pressure
[2] http://wwwnc.cdc.gov/eid/article/21/10/15-0682_article
[3] http://admin.indiaenvironmentportal.org.in/category/author/sandie-m%C3%A9nard
[4] http://admin.indiaenvironmentportal.org.in/category/author/tanila-ben-haddou
[5] http://admin.indiaenvironmentportal.org.in/category/author/arba-pramundita-ramadani-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/emerging-infectious-diseases
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/vector-borne-diseases
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/drugs
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/malaria
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/vector-control
[11] http://admin.indiaenvironmentportal.org.in/category/thesaurus/cambodia