The cross-reactivity of T cells with pathogen- and self-derived peptides has been implicated as a pathway involved in the development of autoimmunity. However, the mechanisms that allow the clonal T cell antigen receptor (TCR) to functionally engage multiple peptide–major histocompatibility complexes (pMHC) are unclear. Here, we studied multiligand discrimination by a human, preproinsulin reactive, MHC class-I–restricted CD8+ T cell clone (1E6) that can recognize over 1 million different peptides.
Original Source [2]
Technology Partners: MimirTech
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/hotspot-autoimmune-t-cell-receptor-binding-underlies-pathogen-and-insulin-peptide
[2] https://www.jci.org/articles/view/85679
[3] http://admin.indiaenvironmentportal.org.in/category/author/david-k-cole
[4] http://admin.indiaenvironmentportal.org.in/category/author/anna-m-bulek
[5] http://admin.indiaenvironmentportal.org.in/category/author/garry-dolton-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/journal-clinical-investigation
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/diabetes
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/micro-organisms
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/research
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/united-kingdom-uk
