Kinase inhibitors are effective cancer therapies, but tumors frequently develop resistance. Current strategies to circumvent resistance target the same or parallel pathways. We report here that targeting a completely different process, autophagy, can overcome multiple BRAF inhibitor resistance mechanisms in brain tumors. BRAFV600Emutations occur in many pediatric brain tumors. We previously reported that these tumors are autophagy-dependent and a patient was successfully treated with the autophagy inhibitor chloroquine after failure of the BRAFV600E inhibitor vemurafenib, suggesting autophagy inhibition overcame the kinase inhibitor resistance. We tested this hypothesis in vemurafenib-resistant brain tumors.
Original Source [2]
Technology Partners: MimirTech
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/autophagy-inhibition-overcomes-multiple-mechanisms-resistance-braf-inhibition-brain
[2] https://elifesciences.org/content/6/e19671
[3] http://admin.indiaenvironmentportal.org.in/category/author/jean-m-mulcahy-levy
[4] http://admin.indiaenvironmentportal.org.in/category/author/shadi-zahedi
[5] http://admin.indiaenvironmentportal.org.in/category/author/andrea-m-griesinger-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/elife
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/cancer
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/drugs
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/child-health
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/medical-research
