The acidic glycoprotein chromogranin A (CHGA) is co-stored/co-secreted with catecholamines and crucial for secretory vesicle biogenesis in neuronal/neuroendocrine cells. CHGA is dysregulated in several cardiovascular diseases, but the underlying mechanisms are not well established. Here, we sought to identify common polymorphisms in the CHGA promoter and to explore the mechanistic basis of their plausible contribution to regulating CHGA protein levels in circulation.
Original Source [2]
Technology Partners: MimirTech
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/haplotype-variant-human-chromogranin-gene-chga-promoter-increases-chga-expression
[2] http://www.jbc.org/content/early/2017/06/30/jbc.M117.778134
[3] http://admin.indiaenvironmentportal.org.in/category/author/lakshmi-subramanian
[4] http://admin.indiaenvironmentportal.org.in/category/author/abrar-khan
[5] http://admin.indiaenvironmentportal.org.in/category/author/prasanna-k-r-allu-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/journal-biological-chemistry
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/heart-diseases
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/medical-research
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/india
