The International Agency for Research on Cancer (IARC) released the latest estimates on the global burden of cancer. The GLOBOCAN 2018 database, accessible online as part of the IARC Global Cancer Observatory, provides estimates of incidence and mortality in 185 countries for 36 types of cancer and for all cancer sites combined. An analysis of these results, published in CA: A Cancer Journal for Clinicians, highlights the large geographical diversity in cancer occurrence and the variations in the magnitude and profile of the disease between and within world regions.