Rhino- and enteroviruses are important human pathogens, against which no antivirals are available.
[2] The best-studied inhibitors are “capsid binders” that fit in a hydrophobic pocket of the viral capsid. Employing a new class of entero-/rhinovirus inhibitors and by means of cryo–electron microscopy (EM), followed by resistance selection and reverse genetics, we discovered a hitherto unknown druggable pocket that is formed by viral proteins VP1 and VP3 and that is conserved across entero-/rhinovirus species.
Original Source [3]
Technology Partners: MimirTech
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/novel-druggable-interprotomer-pocket-capsid-rhino-and-enteroviruses
[2] http://www.indiaenvironmentportal.org.in/files/file/rhino-and-enteroviruses.pdf
[3] https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000281
[4] http://admin.indiaenvironmentportal.org.in/category/author/rana-abdelnabi
[5] http://admin.indiaenvironmentportal.org.in/category/author/james-geraets
[6] http://admin.indiaenvironmentportal.org.in/category/author/yipeng-ma-et-al
[7] http://admin.indiaenvironmentportal.org.in/category/journal/plos-biology
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/diseases
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/micro-organisms
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/research
