The report provides a detailed analysis of the design and implementation of Science, Technology, and Innovation (STI) roadmaps aimed at advancing the Sustainable Development Goals (SDGs) in Sub-Saharan Africa. Developed as part of the collaboration with the Directorate-General for International Partnerships (DG INTPA) of the European Commission for the development of STI for SDGs roadmaps, the report focuses on the experiences of five partner countries: The Gambia, Mauritius, Namibia, Rwanda, and Seychelles. It describes a challenge-oriented framework that aligns STI initiatives with the SDGs, addressing critical sustainability challenges such as food security, climate change resilience, energy transition, and health. The report emphasizes a participatory, evidence-based methodology that integrates local contexts and stakeholder perspectives to ensure relevant and effective STI interventions. Through extensive stakeholder engagement and a comprehensive portfolio of analytical tools, the roadmaps are tailored to each country's unique needs, thereby fostering ownership and commitment among national stakeholders. Additionally, the report highlights the value of challenge-led STI policies and roadmaps, offering strategic recommendations and insights for policymakers, international organizations, and investors. It serves as a practical guide for replicating and adapting the STI for SDGs approach in diverse contexts, aiming to enhance economic growth, social well-being, and environmental sustainability across the region. Concluding with a call to action, the report urges for strengthened collaboration and investment in STI initiatives, emphasizing the need for international cooperation and strategic partnerships to address sustainability challenges and drive sustainable development in Africa.

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