Recent epidemiological studies suggest that diabetes mellitus is a strong risk factor for Alzheimer disease. However, the underlying mechanisms remain largely unknown. In this study, to investigate the pathophysiological interaction between these diseases, we generated animal models that reflect the pathologic conditions of both diseases. We crossed Alzheimer transgenic mice (APP23) with two types of diabetic mice (ob/ob and NSY mice), and analyzed their metabolic and brain pathology. The onset of diabetes exacerbated Alzheimer-like cognitive dysfunction without an increase in brain amyloid-? burden in double-mutant (APP+-ob/ob) mice.
Original Source [2]
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Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/diabetes-accelerated-memory-dysfunction-cerebrovascular-inflammation-and-deposition
[2] http://www.pnas.org/content/107/15/7036
[3] http://admin.indiaenvironmentportal.org.in/category/author/shuko-takeda
[4] http://admin.indiaenvironmentportal.org.in/category/author/naoyuki-sato
[5] http://admin.indiaenvironmentportal.org.in/category/author/kozue-uchio-yamada-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/proceedings-national-academy-sciences
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/health
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/medical-research
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/diabetes
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/mental-health
[11] http://admin.indiaenvironmentportal.org.in/category/thesaurus/neurology
