Brain health is a rapidly expanding field. WHO’s position paper on optimizing brain health across the life course is a technical complement to the recently-adopted Intersectoral global action plan on epilepsy and other neurological disorders 2022–2031. Many determinants are known to affect brain health at different stages of life.
Epilepsy in children is the mostfrequent, heterogeneous and difcultto classify chronic neurologic condition with the etiology found in 35–40% of patients.Our aim is to detectthe metabolic diferences between the epileptic children and the children with no neurological abnormalities in orderto defne the metabolic backgroun
Acute flaccid myelitis (AFM) is a neurologic condition characterized by flaccid limb weakness. After a large number of reports of AFM in 2014, the Centers for Disease Control and Prevention began standardized surveillance in the United States to characterize the disease burden and explore potential etiologies and epidemiologic associations.
Several small experimental studies and cross-sectional observational studies have shown that exposure to the natural environment might protect against attention-deficit hyperactivity disorder (ADHD) or moderate the symptoms of ADHD in children. The researchers aimed to assess whether exposure to the natural environme
Working memory deficits are present in many neuropsychiatric diseases with diagnosis-related severity. However, it is unknown whether this common behavioral abnormality is a continuum explained by a neural mechanism shared across diseases or a set of discrete dysfunctions.
Use of tobacco products is injurious to health in men and women. However, tobacco use by pregnant women receives greater scrutiny because it can also compromise the health of future generations. More men smoke cigarettes than women. Yet the impact of nicotine use by men upon their descendants has not been as widely scrutinized.
On February 1, 2016, the World Health Organization declared that the cluster of microcephaly cases and other neurological disorders constitute public health emergency of international concern. Furthermore, few studies demonstrated that there was an increased evidence of causal relationship of Zika virus (ZIKAV) infection and microcep
Prenatal exposure to organophosphate (OP) pesticides has been linked with poorer neurodevelopment and behaviors related to autism spectrum disorders (ASD) in previous studies, including in the Center for Health Assessment of Mothers and Children of Salinas (CHAMACOS) study, a birth cohort living in the agricultural Salinas Valley in California. The objective of the study is to investigate the association of prenatal exposure to OP pesticides with traits related to ASD, in childhood and adolescents in CHAMACOS.
Aggregation of alpha synuclein has strong implications in Parkinson’s disease. The heterogeneity of folding/aggregation landscape and transient nature of the early intermediates result in difculty in developing a successful therapeutic intervention. Here we used fuorescence measurements at ensemble and single molecule resolution to study how the late and early events of alpha synuclein aggregation modulate each other.
The objective of the study was to investigate the kinetics and metabolism of caffeine in serum from patients with Parkinson disease (PD) and controls using liquid chromatography–mass spectrometry.
