A strong demand of a separate time zone by northeast populace has been a matter of great debate for a very long period. However, no implementable solution to this genuine problem has yet been proposed.
Aggregation of alpha synuclein has strong implications in Parkinson’s disease. The heterogeneity of folding/aggregation landscape and transient nature of the early intermediates result in difculty in developing a successful therapeutic intervention. Here we used fuorescence measurements at ensemble and single molecule resolution to study how the late and early events of alpha synuclein aggregation modulate each other.