Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans, but currently do not transmit efficiently among humans. The viral haemagglutinin (HA) protein is a known host-range determinant as it mediates virus binding to host-specific cellular receptors1, 2, 3. Here we assess the molecular changes in HA that would allow a virus possessing subtype H5 HA to be transmissible among mammals.
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Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/experimental-adaptation-influenza-h5-ha-confers-respiratory-droplet-transmission
[2] http://admin.indiaenvironmentportal.org.in/category/author/masaki-imai
[3] http://admin.indiaenvironmentportal.org.in/category/author/tokiko-watanabe
[4] http://admin.indiaenvironmentportal.org.in/category/author/masato-hatta-et-al
[5] http://admin.indiaenvironmentportal.org.in/category/journal/nature
[6] http://admin.indiaenvironmentportal.org.in/category/thesaurus/influenza
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/viral-diseases
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/avian-flu
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/research
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/respiratory-diseases
[11] http://admin.indiaenvironmentportal.org.in/category/thesaurus/mammals
