The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute inhibition of IKK-ε and TBK1 with amlexanox treatment increases cAMP levels in subcutaneous adipose depots of obese mice, promoting the synthesis and secretion of the cytokine IL-6 from adipocytes and preadipocytes, but not from macrophages. IL-6, in turn, stimulates the phosphorylation of hepatic Stat3 to suppress expression of genes involved in gluconeogenesis, in the process improving glucose handling in obese mice.
Technology Partners: MimirTech
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/subcutaneous-adipose-tissue%E2%80%93liver-signalling-axis-controls-hepatic-gluconeogenesis
[2] http://admin.indiaenvironmentportal.org.in/category/author/shannon-m-reilly
[3] http://admin.indiaenvironmentportal.org.in/category/author/maryam-ahmadian
[4] http://admin.indiaenvironmentportal.org.in/category/author/brian-f-zamarron-et-al
[5] http://admin.indiaenvironmentportal.org.in/category/journal/nature-communications
[6] http://admin.indiaenvironmentportal.org.in/category/thesaurus/obesity
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/research
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/diabetes
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/united-states-america-us
