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Home > Featured Articles > Silica triggers inflammation and ectopic lymphoid neogenesis in the lungs in parallel with accelerated onset of systemic autoimmunity and glomerulonephritis in the lupus-prone NZBWF1 mouse > Silica triggers inflammation and ectopic lymphoid neogenesis in the lungs in parallel with accelerated onset of systemic autoimmunity and glomerulonephritis in the lupus-prone NZBWF1 mouse

Silica triggers inflammation and ectopic lymphoid neogenesis in the lungs in parallel with accelerated onset of systemic autoimmunity and glomerulonephritis in the lupus-prone NZBWF1 mouse [1]

Genetic predisposition and environmental factors influence the development of human autoimmune disease. Occupational exposure to crystalline silica (cSiO2) has been etiologically linked to increased incidence of autoimmunity, including systemic lupus erythematosus (SLE), but the underlying mechanisms are poorly understood. The purpose of this study was to test the hypothesis that early repeated short-term cSiO2 exposure will modulate both latency and severity of autoimmunity in the lupus-prone female NZBWF1 mouse.

Publication Date: 
15/05/2015
Melissa A. Bates [2], Christina Brandenberger [3], Ingeborg Langohr & et al [4]
PLoS ONE [5]
1-25
Tags:
Silicosis [6], Health Effects [7], Research [8], Occupational Health [9], Women [10], United States Of America (US) [11], Mining [12], Uranium [13], Construction Industry [14]

Technology Partners: MimirTech

Source URL: http://admin.indiaenvironmentportal.org.in/feature-article/silica-triggers-inflammation-and-ectopic-lymphoid-neogenesis-lungs-parallel

Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/silica-triggers-inflammation-and-ectopic-lymphoid-neogenesis-lungs-parallel
[2] http://admin.indiaenvironmentportal.org.in/category/author/melissa-bates
[3] http://admin.indiaenvironmentportal.org.in/category/author/christina-brandenberger
[4] http://admin.indiaenvironmentportal.org.in/category/author/ingeborg-langohr-et-al
[5] http://admin.indiaenvironmentportal.org.in/category/journal/plos-one
[6] http://admin.indiaenvironmentportal.org.in/category/thesaurus/silicosis
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/health-effects
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/research
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/occupational-health
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/women
[11] http://admin.indiaenvironmentportal.org.in/category/thesaurus/united-states-america-us
[12] http://admin.indiaenvironmentportal.org.in/category/thesaurus/mining
[13] http://admin.indiaenvironmentportal.org.in/category/thesaurus/uranium
[14] http://admin.indiaenvironmentportal.org.in/category/thesaurus/construction-industry