IL-15 receptor α (IL-15Rα)is a component ofthe heterotrimeric plasma membrane receptor for the pleiotropic cytokine IL-15. However, IL-15Rα is not merely an IL-15 receptor subunit, as mice lacking either IL-15 or IL-15Rα have unique phenotypes.IL-15 and IL-15Rα have been implicated in muscle phenotypes, but a role in muscle physiology has not been defined. Here, we have shown that loss ofIL-15Rα induces a functional oxidative shift in fast muscles, substantially increasing fatigue resistance and exercise capacity.
Original Source [2]
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Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/loss-il-15-receptor-%CE%B1-alters-endurance-fatigability-and-metabolic-characteristics
[2] http://www.jci.org/articles/view/44945/version/2/pdf/render
[3] http://admin.indiaenvironmentportal.org.in/category/author/emidio-e-pistilli
[4] http://admin.indiaenvironmentportal.org.in/category/author/sasha-bogdanovich
[5] http://admin.indiaenvironmentportal.org.in/category/author/fleur-garton-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/journal-clinical-investigation
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/games
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/research
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/united-states-america-us
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/health
[11] http://admin.indiaenvironmentportal.org.in/category/thesaurus/diseases
