Until now, polymyxin resistance has involved chromosomal mutations but has never been reported via horizontal gene transfer. During a routine surveillance project on antimicrobial resistance in commensal Escherichia coli from food animals in China, a major increase of colistin resistance was observed. When an E coli strain, SHP45, possessing colistin resistance that could be transferred to another strain, was isolated from a pig, we conducted further analysis of possible plasmid-mediated polymyxin resistance. Herein, we report the emergence of the first plasmid-mediated polymyxin resistance mechanism, MCR-1, in Enterobacteriaceae.
Original Source [2]
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Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/emergence-plasmid-mediated-colistin-resistance-mechanism-mcr-1-animals-and-human
[2] http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(15)00424-7/fulltext
[3] http://admin.indiaenvironmentportal.org.in/category/author/yi-yun-liu
[4] http://admin.indiaenvironmentportal.org.in/category/author/yang-wang
[5] http://admin.indiaenvironmentportal.org.in/category/author/timothy-r-walsh-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/lancet-infectious-diseases
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/infectious-diseases
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/micro-organisms
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/china
