To determine trends, mortality rates, and costs of antimicrobial resistance in invasive bacterial infections in hospitalized children, we analyzed data from Angkor Hospital for Children, Siem Reap, Cambodia, for 2007–2016. A total of 39,050 cultures yielded 1,341 target pathogens. Resistance rates were high; 82% each of Escherichia coli and Klebsiella pneumoniae isolates were multidrug resistant. Hospital-acquired isolates were more often resistant than community-acquired isolates; resistance trends over time were heterogeneous. K. pneumoniae isolates from neonates were more likely than those from nonneonates to be resistant to ampicillin–gentamicin and third-generation cephalosporins. In patients with community-acquired gram-negative bacteremia, third-generation cephalosporin resistance was associated with increased mortality rates, increased intensive care unit admissions, and 2.26-fold increased healthcare costs among survivors. High antimicrobial resistance in this setting is a threat to human life and the economy. In similar low-resource settings, our methods could be reproduced as a robust surveillance model for antimicrobial resistance.
Original Source [2]
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/antimicrobial-resistance-invasive-bacterial-infections-hospitalized-children
[2] https://wwwnc.cdc.gov/eid/article/24/5/pdfs/17-1830.pdf
[3] http://admin.indiaenvironmentportal.org.in/category/author/andrew-fox-lewis
[4] http://admin.indiaenvironmentportal.org.in/category/author/junko-takata
[5] http://admin.indiaenvironmentportal.org.in/category/author/thyl-miliya-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/emerging-infectious-diseases
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/micro-organisms
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/child-health
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/cambodia
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/infectious-diseases
[11] http://admin.indiaenvironmentportal.org.in/category/thesaurus/drugs
[12] http://admin.indiaenvironmentportal.org.in/category/thesaurus/antibiotic