Can a heterotrophic organism be evolved to synthesize biomass from CO2 directly? So far, non-native carbon fixation in which biomass precursors are synthesized solely from CO2 has remained an elusive grand challenge. Here, we demonstrate how a combination of rational metabolic rewiring, recombinant expression, and laboratory evolution has led to the biosynthesis of sugars and other major biomass constituents by a fully functional Calvin-Benson-Bassham (CBB) cycle in E. coli. In the evolved bacteria, carbon fixation is performed via a non-native CBB cycle, while reducing power and energy are obtained by oxidizing a supplied organic compound (e.g., pyruvate).
Original Source [2]
Technology Partners: MimirTech
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/sugar-synthesis-co2-escherichia-coli
[2] http://www.cell.com/cell/pdfExtended/S0092-8674(16)30668-7
[3] http://admin.indiaenvironmentportal.org.in/category/author/niv-antonovsky
[4] http://admin.indiaenvironmentportal.org.in/category/author/shmuel-gleizer
[5] http://admin.indiaenvironmentportal.org.in/category/author/elad-noor-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/cell
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/micro-organisms
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/carbon-dioxide
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/green-house-gases
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/biomass
