This Practical Handbook is directed to Members of Parliament and Parliamentary Advisors, who are considered “change agents”. It provides a comprehensive and systematic overview of the role that Parliamentarians can play in the creation of reliable, coherent, and transparent “enabling environments” in the range of areas related to investment in agriculture and food systems. The Handbook does so, not through a catalog of prescriptions, but through guidance notes, examples of good practices, and very practical indications. It does not aim to provide a blueprint to be implemented by each Parliament but rather it sets out key stages of processes and mechanisms for MPs and advisors to consider while promoting responsible investment in agriculture and food systems.