Japanese encephalitis (JE) virus (JEV) causes severe epidemic encephalitis across Asia, for which the live attenuated vaccine SA14-14-2 is being used increasingly. JEV is a flavivirus, and is closely related to dengue virus (DENV), which is co-endemic in many parts of Asia, with clinically relevant interactions. There is no information on the human T cell response to SA14-14-2, or whether responses to SA14-14-2 cross-react with DENV. We used live attenuated JE vaccine SA14-14-2 as a model for studying T cell responses to JEV infection in adults, and to determine whether these T cell responses are cross-reactive with DENV, and other flaviviruses.
Original Source [2]
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/cellular-immune-responses-live-attenuated-japanese-encephalitis-je-vaccine-sa14-14-2
[2] http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005263
[3] http://admin.indiaenvironmentportal.org.in/category/author/lance-turtle
[4] http://admin.indiaenvironmentportal.org.in/category/author/filippo-tatullo
[5] http://admin.indiaenvironmentportal.org.in/category/author/tanushka-bali
[6] http://admin.indiaenvironmentportal.org.in/category/journal/plos-neglected-tropical-diseases
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/encephalitis
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/dengue
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/india
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/asia
[11] http://admin.indiaenvironmentportal.org.in/category/thesaurus/drugs
[12] http://admin.indiaenvironmentportal.org.in/category/thesaurus/karnataka
[13] http://admin.indiaenvironmentportal.org.in/category/thesaurus/vaccination