Transcription factor AP-1 plays a central role in HPV-mediated cervical carcinogenesis. AP-1 has also been implicated in chemo-radio-resistance but the mechanism(s) remained unexplored. In the present study, cervical cancer stem-like cells (CaCxSLCs) isolated and enriched from cervical cancer cell lines SiHa and C33a demonstrated an elevated AP-1 DNA-binding activity in comparison to non-stem cervical cancer cells. Upon UV-irradiation, CaCxSLCs showed a UV exposure duration-dependent higher proliferation and highly increased AP-1 activity whereas it was completely abolished in non-stem cancer cells. CaCxSLCs also showed differential overexpression of c-Fos and c-Jun at transcript as well as in protein level.
Original Source [2]
Links:
[1] http://admin.indiaenvironmentportal.org.in/feature-article/cervical-cancer-stem-cells-manifest-radioresistance-association-upregulated-ap-1
[2] https://www.nature.com/articles/s41598-017-05162-x
[3] http://admin.indiaenvironmentportal.org.in/category/author/abhishek-tyagi
[4] http://admin.indiaenvironmentportal.org.in/category/author/kanchan-vishnoi
[5] http://admin.indiaenvironmentportal.org.in/category/author/harsimrut-kaur-et-al
[6] http://admin.indiaenvironmentportal.org.in/category/journal/scientific-reports
[7] http://admin.indiaenvironmentportal.org.in/category/thesaurus/cancer
[8] http://admin.indiaenvironmentportal.org.in/category/thesaurus/radiation
[9] http://admin.indiaenvironmentportal.org.in/category/thesaurus/medical-research
[10] http://admin.indiaenvironmentportal.org.in/category/thesaurus/cervix-uterine-cancer
[11] http://admin.indiaenvironmentportal.org.in/category/thesaurus/developing-countries
[12] http://admin.indiaenvironmentportal.org.in/category/thesaurus/india