The Global Plan for Insecticide Resistance Management in malaria vectors (GPIRM) is a call to action. Through this document, WHO and the Roll Back Malaria Partnership call on governments of malaria-endemic countries, donor organizations, UN agencies, as well as research and industry partners, to implement a five-pillar strategy to tackle the growing threat of insecticide resistance and to facilitate the development of innovative vector control tools and strategies. Coordinated by the Global Malaria Programme, the GPIRM was developed through a broad-based consultation with over 130 stakeholders representing all constituencies of the malaria community, including malaria endemic countries, multilateral agencies, development partners, academia, and industry. The plan contains the latest available evidence on the extent of insecticide resistance around the world, and puts forward a strategy for global and country levels, identifying clear roles and timelines for all stakeholders. The GPIRM also summarizes information about innovative new products being developed and sets out the immediate research and development priorities.