Four geographical zones are defined along the trench that is formed due to the subduction of the Nazca Plate underneath the South American plate; they are denoted A, B, C and D from North to South; zones A, B, and D had a major earthquake after 2010 (Magnitude over 8.0), while zone C has not, thus offering a contrast for comparison. For each zone a sequence of intervals between consecutive seisms with magnitudes ≥ 3.0 is set up and then characterized by Shannon entropy and mutability.