The occurrences of moderate to large magnitude earthquakes and associated subsurface geological processes were critically examined in the backdrop of Indian plate obliquity, stress obliquity, topography, and the late Tertiary regional tectonics for understanding the evolving dynamics and kinematics in the central part of the Himalayas. The higher topographic areas are likely associated with the zones of depressions, and the lower topographic areas are found around the ridges located in the frontal part of the orogen.