International Conference on Climate Change Innovation and Resilience for Sustainable Livelihood is being held in Kathmandu, Nepal from 12-14 January 2015. The conference is a joint effort of The Small Earth Nepal, City University of New York, Colorado State University, Department of Hydrology and Meteorology/Government of Nepal, Department of Livestock Services/Government of Nepal, Agriculture and Forestry University, and Nepal Agricultural Research Council (NARC) with the seed funding from USAID Livestock Innovation Lab.The conference will focus on approaches from the physical and social sciences to support economic development in mountain and lowland South Asia, which faces serious climate hazards along with food security, water, and soil management and environmental justice challenges. This three-day international conference will bring together eminent scientists, government officials, and development workers in nonprofit and for-profit enterprises to discuss promising new approaches for integrating science, policy, and action. We will stress innovative applications of scientific and technical research to promote rural enterprise and broad-based improvements in health, nutrition, and living standards.