International Conference on Modern Mathematical Methods and High Performance Computing in Science and Technology (M3HPCST 2015). The M3HPCST 2015 will provide a forum for engineers and scientists in academic industry and research institute to address the resulting profound challenges and to present and discuss their new ideas, research results, applications and experience on all aspects of Modern Mathematical Methods and High Performance Computing.In the past decade, large scale computing has become a prevalent means of discovery and of "getting things done" in almost all areas of research and technology. The research area of functional analysis, operator Theory, Numerical, Analysis, optimization and scientific computing is playing a central role in this evolution, developing numerical methods for advance simulations in a variety of fields, which include the Physical Sciences, Engineering. Life Sciences and Information Technology.