The study monitored the toxicity of environmentally relevant concentration of pesticides and metals in zebra fish Danio rerio. Zebra fish were exposed to environmentally relevant concentration of pesticides and metals for a period of 14 days. The individual and the combined toxicity of pesticides and metals were evaluated. The pesticides and metals treated groups showed histopathological alterations in the muscle, liver and gill tissues. Significant alterations were seen in liver and gill compared to muscle tissue. Among groups, the changes in group III (pesticides treated) were severe followed by group II (metals treated) and then the group IV (metals and pesticides treated, combined toxicity).