Hydropower is the most important energy source in Mozambique and many other countries in southern Africa. Substantial hydropower development is planned for the Lower Zambezi for the next decades, with regional importance due to integration into the Southern African Power Pool. For such a long-term development, the possible impact of climate change on the future production is of essential interest. The objective of the presented study is to assess hydropower generation in the 21st century for a future hydropower development scenario under two climate scenarios.