Despite the increasing acceptance of traditional medicines in peri-urban areas in South Africa, this rich indigenous knowledge is not adequately documented. Therefore, an ethnobotanical study was undertaken to document medicinal plants grown and maintained in per-urban domestic gardens in the Capricorn District, Limpopo Province. Semi-structured interviews, observation and guided walks with 62 participants were employed to obtain ethnobotanical data on medicinal plants grown and maintained in peri-urban domestic gardens. Data collected included the names of plant species growing and maintained in domestic gardens as medicines, plant parts used, methods of herbal preparation and administration.