The population growth, economic development with the consequent anthropogenic activities at the Nile Delta of Egypt addresses the present-day hydro-environmental status and quality deterioration trends of surface Nile River water. The hydrochemical fingerprints of surface waters revealed the effects of points and non-points sources of pollution. The relative low Cl- and SO4 2- in Nile water of Damietta and Rosetta branches precludes subjacent sources of polluted water. Mixing of surface Nile waters with other drainage polluted ones was revealed by Ludwig-Langelier and Piper diagrams, where there is a general tendency towards no-dominant water type's regime in the Nile River branches with a certain modification in the hydrochemical facies of the drains waters. This modification is due to their pollution by point and non-point sources. The general tendency of water quality deterioration is generally towards the north.