The guidelines issued by the Ministry of Health and Family Welfare for Clinical Management of Acute Encephalitis Syndrome including Japanese encephalitis describe `Acute Encephalitis Syndrome (AES) including Japanese Encephalitis (JE) is a group of clinically similar neurologic manifestation caused by several different viruses, bacteria, fungus, parasites, spirochetes, chemical/toxins etc. There is seasonal and geographical variation in the causative organism. The outbreak of JE usually coincides with the monsoon and post monsoon period when the density of mosquitoes increases while encephalitis due to other viruses especially entero-viruses occurs throughout the year as it is a water borne disease. The case fatality and morbidity is very high among various viral encephalitis specially in JE or entero-virus encephalitis in various parts of India. These guidelines describe salient features of contents in the DPR covering all the slums of selected cities and provide step-by-step approach to prepare such DPR.