CD4+ T cells expressing PD-1, TIGIT and LAG-3 contribute to HIV persistence during ART

HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART). Identifying cellular markers expressed at the surface of these cells may lead to novel therapeutic strategies to reduce the size of the HIV reservoir. We hypothesized that CD4+ T cells expressing immune checkpoint molecules would be enriched in HIV-infected cells in individuals receiving suppressive ART.

Original Source

Publication Date: 
14/07/2016
Rémi Fromentin, Wendy Bakeman, Mariam B. Lawani & et al
PLoS Pathogens
1-19
Attachment(s): 
HIV Persistence during ART.PDF
Tags:
AIDS, Medical Research, Drugs