The impact of projected 21st century climate conditions on streamflow in the Upper Colorado River Basin was estimated using a multi-model ensemble approach wherein the downscaled outputs of 112 future climate projections from 16 global climate models (GCMs) were used to drive a macroscale hydrology model. By the middle of the century, the impacts on streamflow range, over the entire ensemble, from a decrease of approximately 30% to an increase of approximately the same magnitude.