Simultaneous determination of oxytetracycline, 4-epioxytetracycline, ?-apooxytetracycline, tetracycline and ?-apooxytetracycline on C18 columns has been accomplished using a high performance liquid chromatographic method with UV detection. Separation was achieved on a Hypersil BDS RP-C18 column (250 mm

A compilation of the most representative single and multianalyte HPLC methods for the analysis of macrolide antibiotics published during the last two decades is presented in this paper. Its scope is the coverage of two main areas which require the determination of macrolide antibiotics at a low concentration level, i.e. pharmacokinetic studies and residue analysis.

The use of the two macrolides antibiotics Spiramycin (S) and Tylosin (T) as growth promoters in animal feeding has been recently withdrawn in the European Union due to a concern about the outbreaks of farmacoresistance fenomena as a possible hazard for humans.