Mayurbhanj, a hilly district, is rich in ethno medicinal plants. In the present paper 58 plant species belonging to 34 families used in folk medicine have been documented. Due to poor condition of modern healthcare facilities and poverty, indigenous people of the district fully or partially depend on local medicinal plants. An attempt has been made to document traditional knowledge from the baidyas group of Hatikote, Moroda & Rasgovindpur and Udala & Kaptipada blocks of Mayurbhanj district on the treatment of various diseases enumerated.