In 1905, Sir William Osler, the most influential physician of his time, stepped down from the medical faculty of Johns Hopkins University at the age of 55. At his farewell, he emphasized that the “effective, moving, vitalizing work of the world is done between the ages of 25 and 40—these 15 golden years of plenty.” Many of us, who are old but still active like myself, may like to strongly disagree. But the power of the creative prime in this age group is irrefutable.