Sthaulya is a deprecate state of human being. The physical morbidity of Sthaulya is paramount and enhances several disease processes. In the study, the role of Agnimantha (Premna obtusifolia R. Br.) as antiobesity agent has been studied in 26 subjects with severe form of Sthaulya and has been compared in 24 age and sex matched controlled subjects. Subjects of treatment showed remarkable decrease in BMI, triglyceride, cholesterol-HDL ratio, uric acid, LDL-HDL ratio and midtriceps skin-fold thickness. However, these observations are persistent only after continuation of treatment for 9 months. These observations could be more substantiated if a larger study is carried out with assessment of lipoprotein lipase activity and leptine determination. Agnimantha shows significant therapeutic value in obesity. The drug being tikta-katu rasa, ruksha-laghu guna, ushna virya, Katu-vipaka, act nicely for the treatment of obesity. Agnimantha is an ideal drug for the treatment of obesity as it is potent, innocent, cheap and easily available.