The report provides state of knowledge on chemicals in plastics and based on compelling scientific evidence calls for urgent action to address chemicals in plastics as part of the global action on plastic pollution. The “Chemicals in Plastics: A Technical Report” aims to inform the global community about the often-overlooked chemical-related issues of plastic pollution, particularly their adverse impacts on human health and the environment as well as on resource efficiency and circularity. Based on compelling scientific evidence, it further highlights the urgent need to act and outlines possible areas for action. It also aims to support the negotiation process to develop the instrument on plastic pollution based on United Nations Environment Assembly resolution 5/14. The report outlines a set of credible and publicly available scientific studies and initiatives focused on chemicals in plastics and the science-policy interface.