Virtually every business decision is also a decision about the use of natural resources. This paper describes how global warming is affecting water and energy resources, and the challenges and opportunities this presents globally. It summarize the way in which connections among climate, energy, and water are likely to affect business and offer general guidance on how companies can respond to the challenges in an integrated way. The paper highlights how regions of the world that will experience the worst impacts of climate change are those near the equator and overwhelmingly impoverished. And conclude by focusing on the UN Millennium Development Goals (MDGs) as they relate to climate change and alleviating the global water crisis, and suggest ways that business can partner with the UN to work toward their achievement.